One man has died, and a woman is injured after a major head-on collision near Sydney Airport.

The crash occurred on General Holmes Drive at Mascot in the Sydney Airport Tunnel at approximately 6:45am Friday.

7News report that two cars and a truck were involved in the accident.

The man died at the scene, and the woman has been taken to hospital.

Traffic is heavy in the area, with two of the three southbound lanes closed in the tunnel, as well as one of the five northbound lanes.

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Motorists are being encouraged to allow extra travel time.