Homebush Bay Drive is closed southbound at Homebush due to a multi-vehicle crash at the M4 Motorway.
Southbound traffic is being diverted into Concord Road.
One northbound lane is available past the crash site, however there is no eastbound access to the M4
All emergency services and traffic crews are at the scene of the crash.
Motorists are advised to avoid the area and use Concord Road and Silverwater Road as alternatives in both directions.
Five people are reportedly injured with one trapped inside a vehicle.