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Melbourne CBD Driver Had "Mental Health And Drug Issues"

A 10-year-old child is among three people killed by a man with drug, violence and mental health issues who deliberately mowed pedestrians down with a car in Melbourne's Bourke St mall.

A man and a woman in their 30s were also killed by the 26-year-old driver who is now in hospital under police guard.

Police commissioner Graham Ashton said 15 more people were injured by the car in the attack that is not terror-related, five of whom are critical.

"What we do know of the person is there is an extensive family violence history involved," the commissioner told reporters on Friday.

"He has come to our attention on many occasions in the past.

"We have mental health and drug-related issues in the background of this particular person.

"He has been coming to our attention more recently over recent days in relation to assaults, family violence-related assaults."

The Royal Childrens' Hospital said four children, aged three months, two, nine and 12, are in a critical condition.

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Amid the carnage on Bourke St, half a mangled pram was stuck on the bonnet of the car with what appeared to be the other half on the ground at a pedestrian crossing around 100 metres further up the road.

Victorian police chief commissioner Christine Nixon was at the scene and said she saw a pram on the ground and helped the mother.

"She kept asking me 'where's the baby?'," Ms Nixon told ABC 774.

Police believe the man had been on a criminal rampage since the early hours of Friday.

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He is accused of stabbing his brother in Windsor at around 2am, and at around 11.45am police tried to pull him over on the Bolte Bridge armed with guns and tasers but aborted their pursuit because his driving was too dangerous.

Police say a woman, who may have been hostage in the man's car, jumped out of the moving vehicle.

The man was next spotted doing burnouts outside Flinders Street Station before moving down Swanston St and then mowing people down in Bourke St mall.

Mr Ashton said he could not confirm whether two cars seen following the driver on Swanston St were police cars.

The man was also injured, shot in the arm by police who fired at least five times at him before his car crashed and he was arrested.

He was seen lying on the ground dressed only in red underwear and white shoes with several police offices standing over him.

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